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Eric C. Niederhoffer, Ph.D. Associate Professor of Biochemistry and Molecular Biology Southern Illinois University School of Medicine 600 Agriculture Drive, Carbondale, IL 62901-6503 Rm 112 Lindegren, 618-453-6467 eniederhoffer@siumed.edu Copyright 2000- , E.C. Niederhoffer. All Rights Reserved. All trademarks and copyrights are the property of their respective owners.

Zinc-containing alkaline phosphatase (1alk) enzyme from Escherichia coli

• What structural elements are present?
• What is the subunit composition of the proteins?
• What are the major features of the active site?
• What is the distance between metal centers?

Kim, E. E., Wyckoff, H. W. 1991. Reaction mechanism of alkaline phosphatase based on crystal structures. Two-metal ion catalysis. J. Mol. Biol. 218:449-464.

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