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Eric C. Niederhoffer, Ph.D.
Associate Professor of Biochemistry
and Molecular Biology
- Southern Illinois University School
of Medicine
- 600 Agriculture Drive, Carbondale,
IL 62901-6503
Rm 112 Lindegren, 618-453-6467
- eniederhoffer@siumed.edu
- Copyright 2000-
,
E.C. Niederhoffer.
- All Rights Reserved.
All trademarks and copyrights are the property of their respective
owners.
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Lac repressor in the absence (1lbh)
and presence of DNA (1efa) from Escherichia coli
- What structural elements are present
in each molecule?
- What is the subunit composition?
- What is the distance between protein
and DNA?
- What comparisons can be made between
the two structures?
Lewis, M., G. Chang, N.
C. Horton, M. A. Kercher, H. C. Pace, M. A. Schumacher, R. G.
Brennan, and P. Lu.
1996. Crystal structure of the lactose operon repressor and its
complexes with DNA and inducer. Science 271:1247-1254.
Bell, C. E., and M. Lewis. 2000. A closer view of the conformation
of the Lac repressor bound to operator. Nat. Struct. Biol. 7:209-214.
Lac repressor (1lbh)
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Lac repressor with DNA (1efa)
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Alternate View
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- Arg197, Asp274
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Alternate View
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- Ala57, Arg22, Asn25, Gln18, Gln54,
Leu6, Ser16, Ser21, Tyr17, Tyr47
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