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Eric C. Niederhoffer, Ph.D. Associate Professor of Biochemistry and Molecular Biology Southern Illinois University School of Medicine 600 Agriculture Drive, Carbondale, IL 62901-6503 Rm 112 Lindegren, 618-453-6467 eniederhoffer@siumed.edu Copyright 2000- , E.C. Niederhoffer. All Rights Reserved. All trademarks and copyrights are the property of their respective owners.

Lac repressor in the absence (1lbh) and presence of DNA (1efa) from Escherichia coli

• What structural elements are present in each molecule?
• What is the subunit composition?
• What is the distance between protein and DNA?
• What comparisons can be made between the two structures?

Lewis, M., G. Chang, N. C. Horton, M. A. Kercher, H. C. Pace, M. A. Schumacher, R. G. Brennan, and P. Lu. 1996. Crystal structure of the lactose operon repressor and its complexes with DNA and inducer. Science 271:1247-1254.

Bell, C. E., and M. Lewis. 2000. A closer view of the conformation of the Lac repressor bound to operator. Nat. Struct. Biol. 7:209-214.

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