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Eric C. Niederhoffer, Ph.D.

Associate Professor of Biochemistry and Molecular Biology

Southern Illinois University School of Medicine
600 Agriculture Drive, Carbondale, IL 62901-6503
Rm 112 Lindegren, 618-453-6467
eniederhoffer@siumed.edu
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Carbon monoxide dehydrogenase (1jjy) from Carboxydothermus hydrogenoformans

One monomer is presented.

What structural elements are present?
What is the subunit composition of the proteins?
How many metal-sulfur clusters are present?
What are the major features of the active site?
What is the distance between metal centers?
What is the most likely electron transfer pathway? Recall that the enzyme is a dimer.

Dobbek, H., V. Svetlitchnyi, L. Gremer, R. Huber, and O. Meyer. 2001. Crystal structure of a carbon monoxide dehydrogenase reveals a [Ni-4Fe-5S] cluster. Science 293:1281-1285.

Carbon monoxide dehydrogenase (1jjy)

Active Site Views

Push the button to observe the following residues within 3 Å of the iron-sulfur clusters:

Cys39, Cys47, Cys48, Cys51, Cys56, Cys70, Cys295, Cys333, Cys446, Cys476, Cys526, His261 and one water molecule

Push the button to observe the same view without the protein cartoon

Push button

for Original View

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Biochemistry and Molecular Biology Home Page

For more information or comments about this page contact:
eniederhoffer@siumed.edu

Chime SquareTM Animations

Molecular Graphics Resource

Eric C. Niederhoffer, Ph.D.

Associate Professor of Biochemistry and Molecular Biology

One monomer is presented.

Carbon monoxide dehydrogenase (1jjy)

Chime Square^TM Animations