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Eric C. Niederhoffer, Ph.D. Associate Professor of Biochemistry and Molecular Biology Southern Illinois University School of Medicine 600 Agriculture Drive, Carbondale, IL 62901-6503 Rm 112 Lindegren, 618-453-6467 eniederhoffer@siumed.edu Copyright 2000-2002, E.C. Niederhoffer. All Rights Reserved. All trademarks and copyrights are the property of their respective owners.

Phosphoglycerate kinase (13pk) from Trypanosoma brucei

• What structural elements are present in each molecule?
• What is the subunit composition?
• Which residues are most likely to participate as general acid and base catalysts?

Bernstein, B. E., P. A. Michels, and W. G. Hol. 1997. Synergistic effects of substrate-induced conformational changes in phosphoglycerate kinase activation. Nature 385:275-278.

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