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Molecular Graphics Resource

Eric C. Niederhoffer, Ph.D.

Associate Professor of Biochemistry and Molecular Biology

Southern Illinois University School of Medicine
600 Agriculture Drive, Carbondale, IL 62901-6503
Rm 112 Lindegren, 618-453-6467
eniederhoffer@siumed.edu
Copyright 2000- , E.C. Niederhoffer.
All Rights Reserved. All trademarks and copyrights are the property of their respective owners.
Human erythrocyte hemoglobin in the deoxy (1a3n) and oxy (1thb) states

Waller, D. A., and R. C. Liddington. 1990. Refinement of a partially oxygenated T state human haemoglobin at 1.5 Å resolution. Acta Crystallogr. B 46:409-418.

Hemoglobin (1a3n) deoxy

Hemoglobin (1thb) oxy

Active Site Views

  • Push the button  to observe the following residues near the iron center:
His58, His87
  • Push the button  to observe structural changes near the heme center:
His58, His87, Leu83, Leu91, Leu101, Leu136, Phe43, Phe98, Val62
  • Push the button  to observe interactions between alpha1-beta2 interface:
Asn102, Asp94, Asp99, His97, Tyr42
  • Push the button  to observe hydrogen bonds and ion pairs in alpha chains:
Arg141, Asp126, Lys127, Tyr140, Val1, Val34, Val93
  • Push the button  to observe hydrogen bonds and ion pairs in beta chains:
Asp94, His146, Lys40, Tyr145, Val98
  • Push the button  to observe 2,3-bisphosphoglycerate binding site:
His2, His143, Lys82 (Val1 missing)

Push button  for Original View

Active Site Views

  • Push the button  to observe the following residues near the iron center:
His58, His87, and one dioxygen ligand
  • Push the button  to observe structural changes near the heme center:
His58, His87, Leu83, Leu91, Leu101, Leu136, Phe43, Phe98, Val62, and one dioxygen ligand
  • Push the button  to observe interactions between alpha1-beta2 interface:
Asn102, Asp94, Asp99, His97, Tyr42
  • Push the button  to observe hydrogen bonds and ion pairs in alpha chains:
Arg141, Asp126, Lys127, Tyr140, Val1, Val34, Val93
  • Push the button  to observe hydrogen bonds and ion pairs in beta chains:
Asp94, His146, Lys40, Tyr145, Val98
  • Push the button  to observe 2,3-bisphosphoglycerate binding site:
His2, His143, Lys82 (Val1 missing)

Push button  for Original View

 

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For more information or comments about this page contact:
eniederhoffer@siumed.edu