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Eric C. Niederhoffer, Ph.D.

Associate Professor of Biochemistry and Molecular Biology

Southern Illinois University School of Medicine
600 Agriculture Drive, Carbondale, IL 62901-6503
Rm 112 Lindegren, 618-453-6467
eniederhoffer@siumed.edu
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Human erythrocyte hemoglobin in the deoxy (1a3n) and oxy (1thb) states

What structural elements are present in each molecule?
What is the subunit composition?
What is the coordination geometry about each metal ion?
What is the distance between metal centers?
What changes occur upon oxygenation?
What are the characteristics of the allosteric effector (2,3-bisphosphoglycerate or inositol hexaphosphate) binding region?

Waller, D. A., and R. C. Liddington. 1990. Refinement of a partially oxygenated T state human haemoglobin at 1.5 Å resolution. Acta Crystallogr. B 46:409-418.

Hemoglobin (1a3n) deoxy

Hemoglobin (1thb) oxy

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eniederhoffer@siumed.edu