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Eric C. Niederhoffer, Ph.D. Associate Professor of Biochemistry and Molecular Biology Southern Illinois University School of Medicine 600 Agriculture Drive, Carbondale, IL 62901-6503 Rm 112 Lindegren, 618-453-6467 eniederhoffer@siumed.edu Copyright 2000- , E.C. Niederhoffer. All Rights Reserved. All trademarks and copyrights are the property of their respective owners.

Apo (1fes) and copper (1fd8) forms of the metallochaperone protein Atx1 from Saccharomyces cerevisiae. These are averaged NMR structures.

• What structural elements are present in each molecule?
• What is the subunit composition?
• What is the coordination geometry about each metal ion?
• Are there other ligands that may act to transfer metal ions?
• How do these structures compare with MerP and Menkes metalloproteins?

Arnesano, F., L. Banci, I. Bertini, D. L. Huffman, and T. V. O'Halloran. 2001. Solution structure of the Cu(I) and apo forms of the yeast metallochaperone, Atx1. Biochemistry 40:1528-1539.

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