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Eric C. Niederhoffer, Ph.D. Associate Professor of Biochemistry and Molecular Biology Southern Illinois University School of Medicine 600 Agriculture Drive, Carbondale, IL 62901-6503 Rm 112 Lindegren, 618-453-6467 eniederhoffer@siumed.edu Copyright 2000- , E.C. Niederhoffer. All Rights Reserved. All trademarks and copyrights are the property of their respective owners.

Malate dehydrogenase (1b8u) from Aquaspirillum arcticum

• What structural elements are present in each molecule?
• What is the subunit composition?
• Which residues are involved in substrate binding?
• Which residues may act as general acid and base catalysts?

Kim, S. Y., K. Y. Hwang, S.-H. Kim, H.-C. Sung, Y. S. Han, and Y. Cho. 1999. Structural basis for cold adaptation. Sequence, biochemical properties, and crystal structure of malate dehydrogenase from a psychrophile Aquaspirillium arcticum. J. Biol. Chem. 274:11761-11767.

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