"Chime Square" Animations Molecular Graphics Resource

Eric C. Niederhoffer, Ph.D. Associate Professor of Biochemistry and Molecular Biology Southern Illinois University School of Medicine 600 Agriculture Drive, Carbondale, IL 62901-6503 Rm 112 Lindegren, 618-453-6467 eniederhoffer@siumed.edu Copyright 2000- , E.C. Niederhoffer. All Rights Reserved. All trademarks and copyrights are the property of their respective owners.

Aconitase in the inactive (5acn) form from Sus scrofa (pig) and active forms (1c96, 1c97) from Bos taurus (bovine)

• What structural elements are present in each molecule?
• What is the subunit composition?
• What is the distance between metal centers?
• What is the coordination geometry about each metal ion?
• What are the changes that occur upon activation and binding of citrate and isocitrate?

Robbins, A. H., and C. D. Stout. 1989. Structure of activated aconitase: formation of the [4Fe-4S] cluster in the crystal. Proc. Natl. Acad. Sci. U.S.A. 86:3639-3643.

Lloyd, S. J., H. Lauble, G. S. Prasad, and C. D. Stout. 1999. The mechanism of aconitase: 1.8 Å crystal structure of the S642A: citrate complex. Protein Sci. 8:2655-2662.

Chime Square

Biochemistry and Molecular Biology Home Page

For more information or comments about this page contact:
eniederhoffer@siumed.edu