Defects in the glycolytic pathway are associated with hemoglobin function.
a. How are glycolysis and dioxygen transport linked?
Dioxygen affinity of hemoglobin is lowered by 2,3-bisphosphoglycerate. The rate of synthesis of 2,3-bisphosphoglycerate is controlled by the level of 1,3-bisphosphoglycerate, a glycolytic intermediate.
b. How is dioxygen affinity altered by a deficiency of hexokinase?
A deficiency in hexokinase will result in lowered levels of glycolytic intermediates, including a loss of 2,3-bisphosphoglycerate. This leads to higher dioxygen affinity.
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