Iodoacetic acid inhibits glycolysis by inactivating glyceraldehyde-3-phosphate dehydrogenase. Fructose-1,6-bisphosphate accumulates under these conditions. Why does this metabolite accumulate rather than glyceraldehyde-3-phosphate and dihydroxyacetone phosphate, the products of the reaction immediately preceding glyceraldehyde-3-phosphate dehydrogenase?
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