MBMB 451b

Copyright 2000, E.C. Niederhoffer

Lecture #9

You can click on the link to listen to a RealAudio file of the day's lecture. The following description contains the material discussed and the source of the overheads used during the presentation.

Code:

ECN = Created by me

PDF = pdf file

VV = Voet & Voet (Biochemistry)

Lecture 9 (2/15/00) 73 minutes

Announcements

• Visit MBMB451b web site for RealAudio lectures and additional course materials
• Practice the problems from the textbook, I do not have sample problems to post for glycogen metabolism

Lecture #8 review

• Glycolysis, the reactions of glycolysis, fermentation: the anaerobic fate of pyruvate, control of metabolic flux

Glycolysis (PDF file for this topic)

• Metabolism of hexoses other than glucose, fructose, galactose, mannose (PDF p. 20, VV Fig 16-34, PDf p. 21, VV pp. 477,478, Fig 16-35, PDF p. 22, VV p. 479, Fig 16-36)

Glycogen metabolism (PDF file for this topic)

• Glycogen breakdown, glycogen phosphorylase, phosphoglucomutase, glycogen debranching enzyme, thermodynamics of glycogen metabolism: the need for separate pathways of synthesis and breakdown (PDF pp. 1, 2, VV Fig 17-1, PDF p. 3*, VV p. 486, Figs 17-2, 17-3, PDF p. 4, VV Fig 17-5, PDF p. 5, VV Fig 17-4, PDF p. 6)
• Glycogen synthesis, UDP-glucose pyrophosphorylase, glycogen synthase, glycogen brancing enzyme (PDF p. 7, VV Fig 17-6, PDF p. 8, VV Fig 17-7, PDF p. 9, VV Fig 17-8)
• Control of glycogen metabolism, direct allosteric control of glycogen phosphorylase and glycogen synthase, covalent modification of enzymes by cyclic cascades: effector "signal" amplification, glycogen phosphorylase bicyclic cascade (PDF p. 10, VV Fig 17-9, PDF p. 11, VV Fig 17-11, PDF p. 12, VV Fig 17-12, p. 499)
• Please note: the overhead referring to p.3* of the PDF file has a misprint. Phosphorylase a (active, SerOPO₃^2-) and phosphorylase b (less active, Ser) is the correct information. The PDF file has been updated to reflect this correction.

Preview of lecture #10

• Glycogen metabolism, control of glycogen metabolism
• Glycogen storage diseases
• Citric acid cycle

Remember to look over the Study Guides and textbook sections for additional illustrations that may assist in your understanding of the presented material.

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