MBMB 451b
Lecture #8
You can click on the link to listen to a RealAudio file of
the day's lecture. The following description contains the material
discussed and the source of the overheads used during the presentation.
- Code:
- ECN = Created by me
- PDF = pdf file
- VV = Voet & Voet (Biochemistry)
Lecture 8 (2/10/00) 76
minutes
- Announcements
- Visit MBMB451b web site for RealAudio
lectures, additional course materials and sample problems
- A solution to the Bonus
Problem is available
- Lecture #7 review
- Introduction to metabolism, experimental
approaches to the study of metabolism, thermodynamics of phosphate
compounds, oxidation-reduction reactions, thermodynamics of life
- Glycolysis, the glycolytic pathway
- Glycolysis
(PDF file for this
topic)
- The reactions of glycolysis, hexokinase:
first ATP utilization, phosphoglucose isomerase, phosphofructokinase:
second ATP utilization, aldolase, triose phosphate isomerase,
glyceraldehyde-6-phosphate dehydrogenase: first "high-energy"
intermediate formation, phosphoglycerate kinase: first ATP generation,
phosphoglycerate mutase, enolase: second "high-energy"
intermediate formation, pyruvate kinase: second ATP generation
(PDF p. 3, VV p. 447, Figs 16-4, 16-5, PDF p. 4, VV p.
448, Figs 16-6, 16-7, PDF p. 5, VV p. 450, PDF p. 6, VV p. 450,
Figs 16-9, 16-8, p. 453, PDF p. 7, VV p. 453, Fig 16-10, PDF
p. 8, VV p. 457, Figs 16-13, 16-14, PDF p. 9, VV p. 459, Fig
16-16, PDF p. 10, VV p. 460, Figs 16-19, 16-18, 16-20, PDF p.
11, VV p. 462, Fig 16-21, PDF p. 12, VV p. 463, Fig 16-22)
- Please note: the overhead describing
the class I aldolase mechanism should have indicated a Tyr residue
functioning as a general acid-base instead of a Cys and His residue.
Fig 16-9 in your book is correct. Thank you Springfield students
for pointing this out in class.
- Fermentation: the anaerobic fate of
pyruvate, homolactic fermentation, alcoholic fermentation, energetics
of fermentation (PDF p. 13, VV p. 464, Figs 16-24, 16-25,
PDF p. 14, VV Figs 16-26, 16-27, 16-28, 16-30, 16-31)
- Control of metabolic flux, flux generation,
control of glycolysis in muscle (PDF pp. 15, 16, VV Table
16-1, PDF p. 17, VV Fig 16-33, Table 16-2, PDF pp. 18*,
19)
- Please note: the overhead referring
to p.18* of the PDF file has a misprint. The product of the FBPase
reaction is fructose-6-phosphate. The PDF file has been updated
to reflect this correction.
- Preview of lecture #9
- Glycolysis, metabolism of hexoses other
than glucose
- Glycogen metabolism
Remember to look over the Study Guides and textbook sections
for additional illustrations that may assist in your understanding
of the presented material.
MBMB451b
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