MBMB 451b
Lecture #4
You can click on the link to listen to a RealAudio file of
the day's lecture. The following description contains the material
discussed and the source of the overheads used during the presentation.
- Code:
- ECN = Created by me
- PDF = pdf file
- S = Segel (Enzyme Kinetics)
- VV = Voet & Voet (Biochemistry)
Lecture 4 (1/27/00) 70
minutes
- Announcements
- Visit MBMB451b web site for RealAudio
lectures and additional course materials
- Final examination is Monday
May 8, 2000 from 7:50 to 9:50 a.m.
- Lecture #3 review
- Rates of enzymatic reactions, inhibition,
effects of pH, bisubstrate reactions
- Enzymatic catalysis, catalytic mechanisms
- Enzymatic catalysis (PDF
file for this topic)
- Catalytic mechanisms, electrostatic
catalysis, catalysis through proximity and orientation effects,
catalysis by preferential transition state binding (PDF
p. 5, VV p. 378, PDF p. 6)
- Lysozyme, enzyme structure, catalytic
mechanism, testing the Phillips mechanism (PDF p. 7, VV
Figs 14-8, 14-10, 14-12, PDF p. 8, VV Figs 14-11, 14-14)
- Serine proteases, kinetics and catalytic
groups, X-ray structures, catalytic mechanism, testing the catalytic
mechanism, zymogens (PDF p. 9, VV Fig 14-20, PDF p. 10,
VV Figs 14-21, 14-23, 14-24)
- Glutathione reductase (PDF p.
11, VV p. 400, Figs 14-28, 14-29, 14-32)
- Sample problems
- Rates of enzymatic reactions (SP)
- Preview of lecture #5
- Sample problems (SP,
SP, SP, SP)
- Sugars and polysaccharides
Remember to look over the Study Guides and textbook sections
for additional illustrations that may assist in your understanding
of the presented material.
MBMB451b
Home Page